Background It is not known whether infants conceived with useof intracytoplasmic sperm injection or in vitro fertilizationhave a higher risk of birth defects than infants conceived naturally.
Methods We obtained data from three registries in Western Australiaon births, births after assisted conception, and major birthdefects in infants born between 1993 and 1997. We assessed theprevalence of major birth defects diagnosed by one year of agein infants conceived naturally or with use of intracytoplasmicsperm injection or in vitro fertilization.
From the Telethon Institute for Child Health Research and the Center for Child Health Research, University of Western Australia (M.H., J.J.K., C.B.); the Health Department of Western Australia (M.H., S.W.); and the Western Australian Birth Defects Registry (C.B.) — all in Perth, Australia; and the Department of Epidemiology and Public Health, University of Leicester, Leicester, United Kingdom (J.J.K.).
Address reprint requests to Dr. Kurinczuk at the Department of Epidemiology and Public Health, University of Leicester, 22-28 Princess Rd. W., Leicester LE1 6TP, United Kingdom, or at jjk6{at}le.ac.uk.
Major Birth Defects after Assisted Reproduction
Steinkampf M. P., Grifo J., Sills E. S., Palermo G. D., Sutcliffe A. G., Bonduelle M., Taylor B. W., Kurinczuk J. J., Hansen M., Bower C.
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N Engl J Med 2002;
347:1449-1451, Oct 31, 2002.
Correspondence
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