Antiphospholipid antibodies are a family of autoantibodies thatexhibit a broad range of target specificities and affinities,all recognizing various combinations of phospholipids, phospholipid-bindingproteins, or both. The term "antiphospholipid syndrome" wasfirst coined to denote the clinical association between antiphospholipidantibodies and a syndrome of hypercoagulability.1,2 Revisionof the criteria for diagnosis of the antiphospholipid syndromeand the terminology used to describe the disease is an ongoingprocess3 (Table 1).
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Table 1. International Consensus Statement on Preliminary Criteria for the Classification of the Antiphospholipid Syndrome.
Background
The first antiphospholipid antibody, a complement-fixing antibodythat reacted with extracts from bovine hearts, . . . [Full Text of this Article]
Detection of Clinically Relevant Antiphospholipid Antibodies
Pathogenesis
Criteria for Classification and Diagnosis
Epidemiology
Differential Diagnosis
Clinical Features
Pathological Features
Obstetrical Considerations
Catastrophic Antiphospholipid Syndrome
Treatment
Prophylaxis
Treatment after a Thrombotic Event
Source Information
From the Department of Medicine, Section of Nephrology, University of Chicago, Chicago (J.S.L.); the Department of Obstetrics and Gynecology, University of Utah, Salt Lake City (D.W.B.); and the Department of Medicine, Division of Rheumatology, Research Institute of the McGill University Health Centre, Montreal (J.R.).
Address reprint requests to Dr. Rauch at the Montreal General Hospital Research Institute, 1650 Cedar Ave., Montreal, QC H3G 1A4, Canada, or at joyce.rauch@mcgill.ca.
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