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Previous Volume 346:857-858 March 14, 2002 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The telltale wheeze of asthma is the sound of an ill wind blowing through easily irritated, narrowed, and thickened airways. Underlying these changes is bronchial inflammation in which type 2 helper T (Th2) cells, a type of CD4 helper T cell, are prominent. Th2 cells secrete interleukins that promote allergic inflammation and stimulate B cells to produce IgE and other antibodies. In contrast, type 1 helper T (Th1) cells, another class of CD4 T cells, produce interferon- and interleukin-2, which initiate the killing of viruses and other intracellular organisms by activating macrophages and cytotoxic T cells. These two subgroups of . . . [Full Text of this Article]

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