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Previous Volume 346:862-864 March 14, 2002 Number 11 Next

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To the Editor: We wonder about the generalizability of the results of the European Organization for Research and Treatment of Cancer (EORTC) trial of supplementary ("booster") irradiation after lumpectomy (Nov. 8 issue).¹ The rate of recurrence of local breast cancer is now very low in women treated with modern surgical techniques, postoperative whole-breast irradiation (without a supplementary dose), and adjuvant systemic therapy. In a recent randomized trial involving 1234 women with node-negative breast cancer treated with lumpectomy, adjuvant systemic therapy (used selectively), and whole-breast irradiation (50 Gy in 25 fractions or 42.5 Gy in 16 fractions), the rate of recurrence . . . [Full Text of this Article]

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