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Previous Volume 346:864-866 March 14, 2002 Number 11 Next

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To the Editor: Dr. Ada's excellent review of vaccines and vaccination (Oct. 4 issue)¹ was at once comprehensive and detailed. I must, however, take exception to his statement that "the recognition that [measles] immunity can wane after vaccination led to a two-dose vaccination schedule, which prevented the transmission of indigenous measles infections." In fact, most would agree that most cases of measles in the vaccine era occurred in those who were susceptible to measles because of primary vaccine failure.² Waning of immunity appeared to account for a very small number of cases of measles in patients who had received measles . . . [Full Text of this Article]

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