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Volume 346:870 March 14, 2002 Number 11
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Paul Ehrlich's Receptor Immunology: The Magnificent Obsession

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By Arthur M. Silverstein. 202 pp., illustrated. San Diego, Calif., Academic Press, 2002. $75. ISBN 0-12-643765-3.

In 1904, Paul Ehrlich (1854–1915), one of the great architects of medical science, published three articles in the Boston Medical and Surgical Journal, the immediate predecessor of the New England Journal of Medicine. These articles, which concerned Ehrlich's work in immunology, were summaries of the Herter Lectures he had given at Johns Hopkins University. They dealt with immunochemistry, the mechanism of immune hemolysis in vitro, and the side-chain theory of antibody formation. Whether such articles would appear in a clinical journal today is debatable.

At the time of the Herter Lectures, Ehrlich was at the peak of his intellectual . . . [Full Text of this Article]


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