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Correspondence
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Volume 346:1171-1173 April 11, 2002 Number 15
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Nonsteroidal Drugs and Alzheimer's Disease

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To the Editor: The study by in 't Veld et al. (Nov. 22 issue)1 on the prevention of Alzheimer's disease with nonsteroidal antiinflammatory drugs (NSAIDs) includes no mortality data. It is entirely possible that patients who received long-term treatment with NSAIDs were dying sooner from the complications. One may then underestimate the risk of Alzheimer's disease, giving a false positive result. There are also no data on morbidity. The small group of patients receiving NSAIDs for more than 24 months was the only group with a statistically significant reduction in the risk of Alzheimer's disease. It may be inappropriate to . . . [Full Text of this Article]

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