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Previous Volume 346:1251-1252 April 18, 2002 Number 16 Next

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To the Editor: Petersdorf et al. (Dec. 20 issue)¹ suggest that for patients with chronic myelogenous leukemia for whom a donor with an HLA class I mismatch cannot be avoided, "the preferred . . . mismatch should be at a locus for which the recipient is heterozygous, thereby ensuring a concomitant recipient mismatch to counterbalance the donor mismatch." However, 86 percent of the patients in their study with class I mismatches were also mismatched at class II loci. Therefore, the use of donors mismatched at class I loci would result in a significant number of grafts with disparities at both . . . [Full Text of this Article]

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