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Correspondence
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Volume 346:1416-1417 May 2, 2002 Number 18
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Head and Neck Cancer

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To the Editor: Both synchronous and metachronous second cancers in the upper aerodigestive tract are an important problem in patients with head and neck cancer, but this major problem was not discussed in the review by Forastiere et al. (Dec. 27 issue).1 Among patients who survive head and neck cancer, the risk of a second neoplasm is 3 to 7 percent per year.2 The risk of a second squamous-cell neoplasm of the esophagus is as high as 11.8 percent.3,4,5 When a symptomatic esophageal cancer develops in a patient with a history of head and neck cancer, the prognosis is very . . . [Full Text of this Article]

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