To the Editor: In 1992, we reported the results of the prospective,randomized Cancer and Leukemia Group B trial in patients withnewly diagnosed, advanced-stage Hodgkin's disease. The studycompared three regimens: MOPP (mechlorethamine, vincristine,procarbazine, and prednisone) for 6 to 8 months, the standardtreatment at that time; ABVD, a nonalkylating-agentcontainingregimen (doxorubicin, bleomycin, vinblastine, and dacarbazine)for 6 to 8 months; and MOPP alternating with ABVD for 12 months.1
Radiation therapy was not administered. ABVD therapy alone for6 to 8 months resulted in a rate of failure-free survival similarto the rate with a 12-month regimen of . . . [Full Text of this Article]
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