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Clinical Practice
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Volume 346:1468-1474 May 9, 2002 Number 19
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Aspirin for Primary Prevention of Coronary Events
Michael S. Lauer, M.D.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 45-year-old man with a strong family history of premature heart disease has no symptoms of coronary disease and has a normal electrocardiogram. A fasting lipid analysis reveals a total cholesterol level of 225 mg per deciliter (5.8 mmol per liter), a high-density lipoprotein cholesterol level of 35 mg per deciliter (0.9 mmol per liter), a triglyceride level of 150 mg per . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Observational Studies

Randomized Trials

Areas of Uncertainty

Aspirin Dose

Benefits in Specific Subgroups

Other Benefits

Aspirin Resistance

Dual Antiplatelet Therapy

Guidelines

Conclusions and Recommendations


Source Information

From the Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland.

Address reprint requests to Dr. Lauer at the Department of Cardiovascular Medicine, Desk F25, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, or at lauerm@ccf.org.

References


Related Letters:

Aspirin for the Primary Prevention of Coronary Events
Mehta J.L., Mascitelli L., Pezzetta F., Lauer M. S.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:948, Sep 19, 2002. Correspondence

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