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Previous Volume 346:1499 May 9, 2002 Number 19 Next

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To the Editor: The letter from Powers et al. (Jan. 24 issue)¹ challenged our use of the unstratified analysis in evaluating the overall response to empirical antifungal therapy and stated that a Bonferroni correction for multiple testing is required for the comparison of treatment groups with respect to the frequency of breakthrough fungal infections. The basis for our analyses² is the protocol document that was approved before the study by the data safety and monitoring board of the National Institute of Allergy and Infectious Diseases Mycoses Study Group. The plan in the protocol is for an unstratified analysis of the . . . [Full Text of this Article]

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