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Previous Volume 346:1502 May 9, 2002 Number 19 Next

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To the Editor: An invasive approach is still the gold standard for prenatal diagnosis of genetic disorders. Chorionic-villus sampling, the current procedure of choice, allows an early diagnosis, but the miscarriage rate after chorionic-villus sampling is as high as 6.8 percent, and the sampling-failure rate is at least three times the rate with amniocentesis.¹ Cell-free DNA circulating in maternal plasma offers the possibility of a noninvasive approach to prenatal diagnosis.^2,3 This method permits determination of the sex of the fetus with 100 percent accuracy when maternal serum is analyzed during the first trimester of pregnancy.⁴ As a consequence, a new . . . [Full Text of this Article]

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