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Previous Volume 346:1589-1590 May 16, 2002 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The article by Catella-Lawson et al. (Dec. 20 issue)¹ is interesting, particularly in view of the number of patients with cardiac conditions who are candidates for both traditional nonsteroidal antiinflammatory drugs (NSAIDs) and low-dose aspirin.

One result reported by the authors seems to be in conflict with the pharmacokinetics and mechanism of action of ibuprofen and aspirin. In the parallel-group study, aspirin was given two hours before the start of a multiple-dose regimen of ibuprofen. Surprisingly, the protective effect of aspirin was not maintained in these circumstances. If we accept the idea that the mechanism underlying the . . . [Full Text of this Article]

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