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Previous Volume 346:1660-1662 May 23, 2002 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The BRCA1 and BRCA2 genes encode proteins that participate in the cellular response to DNA damage; inactivating mutations in these genes heighten susceptibility to breast and ovarian cancers. The mechanism underlying this tissue specificity is not understood, nor is it clear why mutations in these genes, which are associated with inherited cancer, are not a feature of sporadic breast cancer. The susceptibility to cancer results from the inheritance of one mutant allele of either BRCA1 or BRCA2 (autosomal dominant transmission), followed by the loss of the second allele in breast or ovarian epithelial cells (loss of heterozygosity), leading to complete . . . [Full Text of this Article]

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Oophorectomy in Carriers of BRCA Mutations
Zhuang S. H., Leonard G. D., Swain S. M., Peshkin B. N., DeMarco T. A., Schwartz M. D., Anderson W. F., Brawley O. W., Chang S., Whitfield G. A., Kauff N. D., Robson M. E., Offit K., Rebbeck T. R., Weber B. L.
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N Engl J Med 2002; 347:1037-1040, Sep 26, 2002. Correspondence

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