The systemic amyloidoses comprise a spectrum of acquired andhereditary diseases caused by the deposition of characteristicfibrillar material in various organs and tissues throughoutthe body. These fibrils are 7 to 10 nm wide, rigid, and nonbranching,and they have in common a twisted -pleated sheet structure.They also have unique tinctorial properties, including apple-greenbirefringence when viewed under polarized light after stainingwith Congo red. Several apparently unrelated proteins can formamyloid fibrils and cause specific clinical forms of amyloidosis.
There are two major forms of acquired systemic amyloidosis.The first, systemic amyloid A (AA) amyloidosis, is associated. . . [Full Text of this Article]
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-pleated sheet structure. They also have unique tinctorial properties, including apple-green birefringence when viewed under polarized light after staining with Congo red. Several apparently unrelated proteins can form amyloid fibrils and cause specific clinical forms of amyloidosis. 
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