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A 26-year-old man presented with acute myeloid leukemia (French–American–British stage M1) in January 1996. The leukemic blasts showed complex cytogenetic abnormalities, including a 3q26 break point, an abnormality that is often associated with refractory disease. The patient had no response to induction therapies, and he received palliative outpatient treatment. In December 1996, cranial-nerve palsies and a cough-associated headache developed. Leukemic blasts were present in the cerebrospinal fluid. In April 1997, central vision in his right eye deteriorated. Ophthalmoscopy showed not only multiple retinal hemorrhages and classic Roth's spots (thin arrow), but also a buffy coat in the large subhyaloid hemorrhage . . . [Full Text of this Article] |
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