FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 346:1845-1853 June 13, 2002 Number 24 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Hare, J. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach.

Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes.

Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional class (P<0.001), quality of life (–18.0 vs. –9.0 points, P= 0.001), time on the treadmill during exercise testing (+81 vs. +19 sec, P=0.001), and ejection fraction (+4.6 percent vs. –0.2 percent, P<0.001). In addition, fewer patients in the group assigned to cardiac resynchronization than control patients required hospitalization (8 percent vs. 15 percent) or intravenous medications (7 percent vs. 15 percent) for the treatment of heart failure (P<0.05 for both comparisons). Implantation of the device was unsuccessful in 8 percent of patients and was complicated by refractory hypotension, bradycardia, or asystole in four patients (two of whom died) and by perforation of the coronary sinus requiring pericardiocentesis in two others.

Conclusions Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.

Source Information

From the University of Kentucky College of Medicine, Lexington (W.T.A., W.G.F.); Emory University and Crawford Long Hospital, Atlanta (A.L.S., D.B.D., A.R.L.); the University of Pennsylvania, Philadelphia (E.L., D.Z.K.); Columbia University College of Physicians and Surgeons, New York (M.P.); Mayo Medical Center, Rochester, Minn. (A.L.C., D.L.H.); and Long Beach Memorial Medical Center, Long Beach, Calif. (M.E., J.M.).

Other authors were Robin J. Trupp, M.S.N. (University of Kentucky, Lexington), Jackie Underwood, B.S.N. (Emory University and Crawford Long Hospital, Atlanta), Faith Pickering, B.S.N. (University of Pennsylvania, Philadelphia), Cindy Truex, B.S.N. (Mayo Medical Center, Rochester, Minn.), and Peggy McAtee, M.S.N. (Long Beach Memorial Hospital, Long Beach, Calif.).

Address reprint requests to Dr. Abraham at the University of Kentucky College of Medicine, Division of Cardiovascular Medicine, Rm. L-543, Kentucky Clinic, 740 S. Limestone St., Lexington, KY 40536-0284, or at wtabra2{at}uky.edu.

Full Text of this Article

Related Letters:

Cardiac Resynchronization Therapy for Heart Failure
Bax J. J., Van der Wall E. E., Schalij M. J., Gottlieb S. S., Fisher M. L., Abraham W. T., the MIRACLE Study Group
Extract | Full Text | PDF  
N Engl J Med 2002; 347:1803-1804, Nov 28, 2002. Correspondence

This article has been cited by other articles:

• Nazeri, A., Massumi, A., Rasekh, A., Saeed, M., Frank, C., Wilson, J. M., Lopez, J. A., Razavi, M. (2008). Cardiac resynchronization therapy may improve symptoms of congestive heart failure in patients without electrical or mechanical dyssynchrony. Europace 0: eun326v1-3 [Abstract] [Full Text]  
• Linde, C., Abraham, W. T., Gold, M. R., St. John Sutton, M., Ghio, S., Daubert, C., REVERSE (REsynchronization reVErses Remodeling in, (2008). Randomized Trial of Cardiac Resynchronization in Mildly Symptomatic Heart Failure Patients and in Asymptomatic Patients With Left Ventricular Dysfunction and Previous Heart Failure Symptoms. J Am Coll Cardiol 52: 1834-1843 [Abstract] [Full Text]  
• Duray, G. Z., Schmitt, J., Cicek-Hartvig, S., Hohnloser, S. H., Israel, C. W. (2008). Complications leading to surgical revision in implantable cardioverter defibrillator patients: comparison of patients with single-chamber, dual-chamber, and biventricular devices. Europace 0: eun322v1-6 [Abstract] [Full Text]  
• Turley, A. J., Raja, S. G., Salhiyyah, K., Nagarajan, K. (2008). Does cardiac resynchronisation therapy improve survival and quality of life in patients with end-stage heart failure?. ICVTS 7: 1141-1146 [Abstract] [Full Text]  
• Naqvi, T Z, Rafique, A M, Swerdlow, C, Verma, S, Siegel, R J, Tolstrup, K, Kerwin, W, Goodman, J, Gallik, D, Gang, E, Peter, C T (2008). Predictors of reduction in mitral regurgitation in patients undergoing cardiac resynchronisation treatment. Heart 94: 1580-1588 [Abstract] [Full Text]  
• Tang, W. H. W., Mullens, W., Borowski, A. G., Tong, W., Shrestha, K., Troughton, R. W., Martin, M. G., Kassimatis, K., Agler, D., Jasper, S., Grimm, R. A., Starling, R. C., Klein, A. L. (2008). Relation of mechanical dyssynchrony with underlying cardiac structure and performance in chronic systolic heart failure: implications on clinical response to cardiac resynchronization. Europace 10: 1370-1374 [Abstract] [Full Text]  
• Jauvert, G., Rousseau-Paziaud, J., Villain, E., Iserin, L., Hidden-Lucet, F., Ladouceur, M., Sidi, D. (2008). Effects of cardiac resynchronization therapy on echocardiographic indices, functional capacity, and clinical outcomes of patients with a systemic right ventricle. Europace 0: eun319v1-7 [Abstract] [Full Text]  
• Sredniawa, B., Lenarczyk, R., Kowalski, O., Pruszkowska-Skrzep, P., Kowalczyk, J., Musialik-Lydka, A., Cebula, S., Kalarus, Z. (2008). Sleep apnoea as a predictor of mid- and long-term outcome in patients undergoing cardiac resynchronization therapy. Europace 0: eun310v1-10 [Abstract] [Full Text]  
• Parsai, C., Bijnens, B., Sutherland, G. R., Baltabaeva, A., Claus, P., Marciniak, M., Paul, V., Scheffer, M., Donal, E., Derumeaux, G., Anderson, L. (2008). Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms. Eur Heart J 0: ehn481v1-10 [Abstract] [Full Text]  
• Rocchi, G., Bertini, M., Biffi, M., Ziacchi, M., Biagini, E., Gallelli, I., Martignani, C., Cervi, E., Ferlito, M., Rapezzi, C., Branzi, A., Boriani, G. (2008). Exercise stress echocardiography is superior to rest echocardiography in predicting left ventricular reverse remodelling and functional improvement after cardiac resynchronization therapy. Eur Heart J 0: ehn483v1-9 [Abstract] [Full Text]  
• Van Kriekinge, S. D., Nishina, H., Ohba, M., Berman, D. S., Germano, G. (2008). Automatic Global and Regional Phase Analysis from Gated Myocardial Perfusion SPECT Imaging: Application to the Characterization of Ventricular Contraction in Patients with Left Bundle Branch Block. JNM 49: 1790-1797 [Abstract] [Full Text]  
• Zhang, Q, Fung, J W-H, Yip, G W K, Chan, J Y-S, Lee, A P-W, Lam, Y-Y, Wu, L-W, Wu, E B, Yu, C-M (2008). Improvement of left ventricular myocardial short-axis, but not long-axis function or torsion after cardiac resynchronisation therapy: an assessment by two-dimensional speckle tracking. Heart 94: 1464-1471 [Abstract] [Full Text]  
• Buck, S., Maass, A. H., Nieuwland, W., Anthonio, R. L., Van Veldhuisen, D. J., Van Gelder, I. C. (2008). Impact of interventricular lead distance and the decrease in septal-to-lateral delay on response to cardiac resynchronization therapy. Europace 10: 1313-1319 [Abstract] [Full Text]  
• Fatemi, M., Etienne, Y., Castellant, P., Blanc, J.-J. (2008). Primary failure of cardiac resynchronization therapy: what are the causes and is it worth considering a second attempt? A single-centre experience. Europace 10: 1308-1312 [Abstract] [Full Text]  
• Foley, P. W.X., Chalil, S., Khadjooi, K., Smith, R. E.A., Frenneaux, M. P., Leyva, F. (2008). Long-term effects of cardiac resynchronization therapy in octogenarians: a comparative study with a younger population. Europace 10: 1302-1307 [Abstract] [Full Text]  
• Kontogeorgis, A., Li, X., Kang, E. Y., Feig, J. E., Ponzio, M., Kang, G., Kaba, R. A., Wit, A. L., Fisher, E. A., Morley, G. E., Peters, N. S., Coetzee, W. A., Gutstein, D. E. (2008). Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents. Am. J. Physiol. Heart Circ. Physiol. 295: H1905-H1916 [Abstract] [Full Text]  
• Gorcsan, J. III, Suffoletto, M. S. (2008). The role of tissue Doppler and strain imaging in predicting response to CRT. Europace 10: iii80-iii87 [Abstract] [Full Text]  
• Parthenakis, F. I., Patrianakos, A. P., Simantirakis, E. N., Vardas, P. E. (2008). CRT and exercise capacity in heart failure: the impact of mitral valve regurgitation. Europace 10: iii96-iii100 [Abstract] [Full Text]  
• Zhang, Q., Yip, G. W.-K., Yu, C.-M. (2008). Approaching regional left atrial function by tissue Doppler velocity and strain imaging. Europace 10: iii62-iii69 [Abstract] [Full Text]  
• Di Biase, L., Gasparini, M., Lunati, M., Santini, M., Landolina, M., Boriani, G., Curnis, A., Bocchiardo, M., Vincenti, A., Denaro, A., Valsecchi, S., Natale, A., Padeletti, L., on behalf of the InSync/InSync ICD Italian Registr, (2008). Antiarrhythmic Effect of Reverse Ventricular Remodeling Induced by Cardiac Resynchronization Therapy: The InSync ICD (Implantable Cardioverter-Defibrillator) Italian Registry. J Am Coll Cardiol 52: 1442-1449 [Abstract] [Full Text]  
• Khan, M. N., Jais, P., Cummings, J., Di Biase, L., Sanders, P., Martin, D. O., Kautzner, J., Hao, S., Themistoclakis, S., Fanelli, R., Potenza, D., Massaro, R., Wazni, O., Schweikert, R., Saliba, W., Wang, P., Al-Ahmad, A., Beheiry, S., Santarelli, P., Starling, R. C., Russo, A. D., Pelargonio, G., Brachmann, J., Schibgilla, V., Bonso, A., Casella, M., Raviele, A., Haissaguerre, M., Natale, A., the PABA-CHF Investigators, (2008). Pulmonary-Vein Isolation for Atrial Fibrillation in Patients with Heart Failure. NEJM 359: 1778-1785 [Abstract] [Full Text]  
• Ypenburg, C., van Bommel, R. J., Delgado, V., Mollema, S. A., Bleeker, G. B., Boersma, E., Schalij, M. J., Bax, J. J. (2008). Optimal Left Ventricular Lead Position Predicts Reverse Remodeling and Survival After Cardiac Resynchronization Therapy. J Am Coll Cardiol 52: 1402-1409 [Abstract] [Full Text]  
• Upadhyay, G. A., Choudhry, N. K., Auricchio, A., Ruskin, J., Singh, J. P. (2008). Cardiac Resynchronization in Patients With Atrial Fibrillation: A Meta-Analysis of Prospective Cohort Studies. J Am Coll Cardiol 52: 1239-1246 [Abstract] [Full Text]  
• Di Biase, L., Auricchio, A., Sorgente, A., Civello, K., Klersy, C., Faletra, F., Riedlbauchova, L., Patel, D., Arruda, M., Schweikert, R. A., Martin, D. O., Saliba, W. I., Moccetti, T., Wilkoff, B. L., Natale, A. (2008). The magnitude of reverse remodelling irrespective of aetiology predicts outcome of heart failure patients treated with cardiac resynchronization therapy. Eur Heart J 29: 2497-2505 [Abstract] [Full Text]  
• Stanton, T., Hawkins, N. M., Hogg, K. J., Goodfield, N. E.R., Petrie, M. C., McMurray, J. J.V. (2008). How should we optimize cardiac resynchronization therapy?. Eur Heart J 29: 2458-2472 [Abstract] [Full Text]  
• Evonich, R. F., Stephens, J. C., Merhi, W., Dukkipati, S., Tepe, N., Shannon, F., Altshuler, J., Sakwa, M., Bassett, J., Hanson, E., Boura, J., O'Neill, W. W., Haines, D. E. (2008). The role of temporary biventricular pacing in the cardiac surgical patient with severely reduced left ventricular systolic function.. J. Thorac. Cardiovasc. Surg. 136: 915-921 [Abstract] [Full Text]  
• Atoui, R., Essebag, V., Wu, V., Ge, Y., Auclair, M.-H., Hadjis, T., Shum-Tim, D. (2008). Biventricular pacing for end-stage heart failure: early experience in surgical vs. transvenous left ventricular lead placement. ICVTS 7: 839-844 [Abstract] [Full Text]  
• Authors/Task Force Members, , Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Tendera, M., Auricchio, A., Bax, J., Bohm, M., Corra, U., della Bella, P., Elliott, P. M., Follath, F., Gheorghiade, M., Hasin, Y., Hernborg, A., Jaarsma, T., Komajda, M., Kornowski, R., Piepoli, M., Prendergast, B., Tavazzi, L., Vachiery, J.-L., Verheugt, F. W. A., Zamorano, J. L., Zannad, F. (2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29: 2388-2442 [Full Text]  
• Altin, T., Candemir, B., Ozkaramanli, D., Akyurek, O., Karaoguz, R., Guldal, M. (2008). Acute pulmonary oedema during cardiac resynchronization therapy device implantation: management with the activation of intra-aortic balloon pump. Europace 10: 1232-1234 [Abstract] [Full Text]  
• Valzania, C., Eriksson, M. J., Boriani, G., Gadler, F. (2008). Cardiac resynchronization therapy during rest and exercise: comparison of two optimization methods. Europace 10: 1161-1169 [Abstract] [Full Text]  
• Miura, M., Wakayama, Y., Endoh, H., Nakano, M., Sugai, Y., Hirose, M., ter Keurs, H. E.D.J., Shimokawa, H. (2008). Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic-delayed afterdepolarizations in rat cardiac muscle. Cardiovasc Res 80: 55-61 [Abstract] [Full Text]  
• Conen, D., Torres, J., Ridker, P. M (2008). Differential Citation Rates of Major Cardiovascular Clinical Trials According to Source of Funding: A Survey From 2000 to 2005. Circulation 118: 1321-1327 [Abstract] [Full Text]  
• Lim, P., Buakhamsri, A., Popovic, Z. B., Greenberg, N. L., Patel, D., Thomas, J. D., Grimm, R. A. (2008). Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy. Circulation 118: 1130-1137 [Abstract] [Full Text]  
• Gorcsan, J. III (2008). Is the Magnet a Better Crystal Ball for Predicting Response to Cardiac Resynchronization Therapy?. J Am Coll Cardiol Img 1: 569-571 [Full Text]  
• Zaret, B. L. (2008). Cardiac Imaging and Cardiac Resynchronization Therapy: Time to Get in Phase. J Am Coll Cardiol Img 1: 614-616 [Full Text]  
• Sood, M. M., Pauly, R. P., Rigatto, C., Komenda, P. (2008). Left ventricular dysfunction in the haemodialysis population. NDT Plus 1: 199-205 [Abstract] [Full Text]  
• Chang, S-A, Kim, H-K, Lee, H-Y, Choi, S-Y, Koo, B-K, Kim, Y-J, Sohn, D-W, Oh, B-H, Park, Y-B, Choi, Y-S, Kang, H-J, Kim, H-S (2008). Restoration of left ventricular synchronous contraction after acute myocardial infarction by stem cell therapy: new insights into the therapeutic implication of stem cell therapy for acute myocardial infarction. Heart 94: 995-1001 [Abstract] [Full Text]  
• Bordachar, P., Iriart, X., Chabaneix, J., Sacher, F., Lafitte, S., Jais, P., Haissaguerre, M., Clementy, J., Dos Santos, P., Thambo, J.-B. (2008). Presence of ventricular dyssynchrony and haemodynamic impact of right ventricular pacing in adults with repaired Tetralogy of Fallot and right bundle branch block. Europace 10: 967-971 [Abstract] [Full Text]  
• Lim, S. H., Lip, G. Y.H., Sanderson, J. E. (2008). Ventricular optimization of biventricular pacing: a systematic review. Europace 10: 901-906 [Abstract] [Full Text]  
• Gradaus, R, Stuckenborg, V, Loher, A, Kobe, J, Reinke, F, Gunia, S, Vahlhaus, C, Breithardt, G, Bruch, C (2008). Diastolic filling pattern and left ventricular diameter predict response and prognosis after cardiac resynchronisation therapy. Heart 94: 1026-1031 [Abstract] [Full Text]  
• Remme, W. J., McMurray, J. J.V., Hobbs, F.D. R., Cohen-Solal, A., Lopez-Sendon, J., Boccanelli, A., Zannad, F., Rauch, B., Keukelaar, K., Macarie, C., Ruzyllo, W., Cline, C., for the SHAPE Study Group, (2008). Awareness and perception of heart failure among European cardiologists, internists, geriatricians, and primary care physicians. Eur Heart J 29: 1739-1752 [Abstract] [Full Text]  
• Popovic, Z. B., Thomas, J. D. (2008). In Search of a Holy Grail: Predicting Cardiac Resynchronization Therapy Outcomes by Echocardiography. Circ Cardiovasc Imaging 1: 3-5 [Full Text]  
• Miyazaki, C., Lin, G., Powell, B. D., Espinosa, R. E., Bruce, C. J., Miller, F. A. Jr, Karon, B. L., Rea, R. F., Hayes, D. L., Oh, J. K. (2008). Strain Dyssynchrony Index Correlates With Improvement in Left Ventricular Volume After Cardiac Resynchronization Therapy Better Than Tissue Velocity Dyssynchrony Indexes. Circ Cardiovasc Imaging 1: 14-22 [Abstract] [Full Text]  
• Prinzen, F. W., Auricchio, A. (2008). Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Not Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available. Circ Cardiovasc Imaging 1: 70-78 [Full Text]  
• Fonarow, G. C., Yancy, C. W., Albert, N. M., Curtis, A. B., Stough, W. G., Gheorghiade, M., Heywood, J. T., McBride, M. L., Mehra, M. R., O'Connor, C. M., Reynolds, D., Walsh, M. N. (2008). Heart Failure Care in the Outpatient Cardiology Practice Setting: Findings From IMPROVE HF. Circ Heart Fail 1: 98-106 [Abstract] [Full Text]  
• Gasparini, M., Auricchio, A., Metra, M., Regoli, F., Fantoni, C., Lamp, B., Curnis, A., Vogt, J., Klersy, C., for the Multicentre Longitudinal Observational Stu, (2008). Long-term survival in patients undergoing cardiac resynchronization therapy: the importance of performing atrio-ventricular junction ablation in patients with permanent atrial fibrillation. Eur Heart J 29: 1644-1652 [Abstract] [Full Text]  
• Kara, T., Novak, M., Nykodym, J., Bybee, K. A., Meluzin, J., Orban, M., Novakova, Z., Lipoldova, J., Hayes, D. L., Soucek, M., Vitovec, J., Somers, V. K. (2008). Short-term Effects of Cardiac Resynchronization Therapy on Sleep-Disordered Breathing in Patients With Systolic Heart Failure. Chest 134: 87-93 [Abstract] [Full Text]  
• Khadjooi, K, Foley, P W, Chalil, S, Anthony, J, Smith, R E A, Frenneaux, M P, Leyva, F (2008). Long-term effects of cardiac resynchronisation therapy in patients with atrial fibrillation. Heart 94: 879-883 [Abstract] [Full Text]  
• Kassai, I., Foldesi, C., Szekely, A., Szili-Torok, T. (2008). New method for cardiac resynchronization therapy: transapical endocardial lead implantation for left ventricular free wall pacing. Europace 10: 882-883 [Abstract] [Full Text]  
• Ferreira, A. M., Adragao, P., Cavaco, D. M., Candeias, R., Morgado, F. B., Santos, K. R., Santos, E., Silva, J. A. (2008). Benefit of cardiac resynchronization therapy in atrial fibrillation patients vs. patients in sinus rhythm: the role of atrioventricular junction ablation. Europace 10: 809-815 [Abstract] [Full Text]  
• Mandysova, E., Mraz, T., Taborsky, M., Niederle, P. (2008). Reproducibility of tissue Doppler parameters of asynchrony in patients with advanced LV dysfunction. Eur J Echocardiogr 9: 509-515 [Abstract] [Full Text]  
• Manisty, C. H., Willson, K., Davies, J. E. R., Whinnett, Z. I., Baruah, R., Mebrate, Y., Kanagaratnam, P., Peters, N. S., Hughes, A. D., Mayet, J., Francis, D. P. (2008). Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R219-R227 [Abstract] [Full Text]  
• Zanon, F., Aggio, S., Baracca, E., Pastore, G., Corbucci, G., Boaretto, G., Braggion, G., Piergentili, C., Rigatelli, G., Roncon, L. (2008). Ventricular-arterial coupling in patients with heart failure treated with cardiac resynchronization therapy: may we predict the long-term clinical response?. Eur J Echocardiogr 0: jen184v1-6 [Abstract] [Full Text]  
• Wang, N. C., Maggioni, A. P., Konstam, M. A., Zannad, F., Krasa, H. B., Burnett, J. C. Jr, Grinfeld, L., Swedberg, K., Udelson, J. E., Cook, T., Traver, B., Zimmer, C., Orlandi, C., Gheorghiade, M., for the Efficacy of Vasopressin Antagonism in Hear, (2008). Clinical Implications of QRS Duration in Patients Hospitalized With Worsening Heart Failure and Reduced Left Ventricular Ejection Fraction. JAMA 299: 2656-2666 [Abstract] [Full Text]  
• Sweeney, M. O., Prinzen, F. W. (2008). Ventricular Pump Function and Pacing: Physiological and Clinical Integration. Circ Arrhythmia Electrophysiol 1: 127-139 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: e1-e62 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Mark Estes, N.A. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: 2085-2105 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: 2820-2840 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: e350-e408 [Full Text]  
• Chung, E. S., Leon, A. R., Tavazzi, L., Sun, J.-P., Nihoyannopoulos, P., Merlino, J., Abraham, W. T., Ghio, S., Leclercq, C., Bax, J. J., Yu, C.-M., Gorcsan, J. III, St John Sutton, M., De Sutter, J., Murillo, J. (2008). Results of the Predictors of Response to CRT (PROSPECT) Trial. Circulation 117: 2608-2616 [Abstract] [Full Text]  
• Miyazaki, C., Powell, B. D., Bruce, C. J., Espinosa, R. E., Redfield, M. M., Miller, F. A., Hayes, D. L., Cha, Y.-M., Oh, J. K. (2008). Comparison of Echocardiographic Dyssynchrony Assessment by Tissue Velocity and Strain Imaging in Subjects With or Without Systolic Dysfunction and With or Without Left Bundle-Branch Block. Circulation 117: 2617-2625 [Abstract] [Full Text]  
• Butter, C., Rastogi, S., Minden, H.-H., Meyhofer, J., Burkhoff, D., Sabbah, H. N. (2008). Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure.. J Am Coll Cardiol 51: 1784-1789 [Abstract] [Full Text]  
• Buck, S., Rienstra, M., Maass, A. H., Nieuwland, W., Van Veldhuisen, D. J., Van Gelder, I. C. (2008). Cardiac resynchronization therapy in patients with heart failure and atrial fibrillation: importance of new-onset atrial fibrillation and total atrial conduction time. Europace 10: 558-565 [Abstract] [Full Text]  
• Haghjoo, M., Bagherzadeh, A., Farahani, M. M., Haghighi, Z. O., Sadr-Ameli, M. A. (2008). Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects. Europace 10: 566-571 [Abstract] [Full Text]  
• Leclercq, C., Gadler, F., Kranig, W., Ellery, S., Gras, D., Lazarus, A., Clementy, J., Boulogne, E., Daubert, J.-C., for the TRIP-HF (Triple Resynchronization In Paced, (2008). A Randomized Comparison of Triple-Site Versus Dual-Site Ventricular Stimulation in Patients With Congestive Heart Failure. J Am Coll Cardiol 51: 1455-1462 [Abstract] [Full Text]  
• Anderson, L. J., Miyazaki, C., Sutherland, G. R., Oh, J. K. (2008). Patient Selection and Echocardiographic Assessment of Dyssynchrony in Cardiac Resynchronization Therapy. Circulation 117: 2009-2023 [Full Text]  
• Borggrefe, M. M., Lawo, T., Butter, C., Schmidinger, H., Lunati, M., Pieske, B., Misier, A. R., Curnis, A., Bocker, D., Remppis, A., Kautzner, J., Stuhlinger, M., Leclerq, C., Taborsky, M., Frigerio, M., Parides, M., Burkhoff, D., Hindricks, G. (2008). Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure. Eur Heart J 29: 1019-1028 [Abstract] [Full Text]  
• Yoshida, K., Yokoyama, Y., Seo, Y., Sekiguchi, Y., Aonuma, K. (2008). Triangle ventricular pacing in a non-responder to conventional bi-ventricular pacing. Europace 10: 502-504 [Abstract] [Full Text]  
• Bourge, R. C., Abraham, W. T., Adamson, P. B., Aaron, M. F., Aranda, J. M. Jr, Magalski, A., Zile, M. R., Smith, A. L., Smart, F. W., O'Shaughnessy, M. A., Jessup, M. L., Sparks, B., Naftel, D. L., Stevenson, L. W., on behalf of the COMPASS-HF Study Group, (2008). Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study.. J Am Coll Cardiol 51: 1073-1079 [Abstract] [Full Text]  
• Inage, T., Yoshida, T., Hiraki, T., Ohe, M., Takeuchi, T., Nagamoto, Y., Fukuda, Y., Gondo, T., Imaizumi, T. (2008). Chronic cardiac resynchronization therapy reverses cardiac remodelling and improves invasive haemodynamics of patients with severe heart failure on optimal medical treatment. Europace 10: 379-383 [Abstract] [Full Text]  
• Albertsen, A. E., Nielsen, J. C., Poulsen, S. H., Mortensen, P. T., Pedersen, A. K., Hansen, P. S., Jensen, H. K., Egeblad, H. (2008). Biventricular pacing preserves left ventricular performance in patients with high-grade atrio-ventricular block: a randomized comparison with DDD(R) pacing in 50 consecutive patients. Europace 10: 314-320 [Abstract] [Full Text]