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Previous Volume 346:1912-1913 June 13, 2002 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Although the development of the digital-protein-truncation test described by Traverso et al. (Jan. 31 issue)¹ is a "tour de force,"² the 0 percent false positive rate for the detection of mutations in the adenomatous polyposis coli (APC) gene — considered an "important component" of the study¹ and noted in the news³ — will probably increase substantially when the spectrum of subjects⁴ is broadened to include the more than 30 percent of Americans with adenomas smaller than 1.0 cm, for two reasons. First, mutant APC is thought to occur very early in the development of an . . . [Full Text of this Article]

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