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Correspondence
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Volume 346:1913-1914 June 13, 2002 Number 24
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Fluconazole Prophylaxis against Fungal Infection in Preterm Infants

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 by Kaufman, D.
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To the Editor: Kaufman et al. (Dec. 6 issue)1 define invasive fungal infections by positive cultures of blood, urine, or cerebrospinal fluid. However, it is difficult to evaluate whether all reported cases of fungal infections represented candida sepsis rather than candida colonization. The authors do not specify whether blood samples were obtained from central catheters or from peripheral vessels; it is difficult to distinguish systemic fungemia from a positive culture due to a contaminated catheter.2 Two isolated episodes of candiduria were considered to represent invasive infections, but isolated candiduria may reflect transient colonization in a patient receiving antibiotic therapy.2 The . . . [Full Text of this Article]

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