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Editorial
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Volume 346:1999-2001 June 20, 2002 Number 25
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Hypertension, Angiotensin II, and Oxidative Stress

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 by Higashi, Y.
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Renovascular hypertension is a potentially curable form of secondary hypertension generally due to either atherosclerosis or fibromuscular dysplasia of one or both renal arteries.1,2 The critical element promoting hypertension in this disorder is reduced arterial perfusion to one or both kidneys,1 leading to increased production of renin, which elevates circulating angiotensin II levels.1,2 The resultant high-renin hypertensive state is associated with moderate-to-severe elevation of blood pressure, with an attendant high risk of cardiovascular disease and progressive loss of renal function in the flow-deprived kidney.1 Treatment of renovascular hypertension with angioplasty, stenting, or surgery affords an opportunity to reduce blood pressure . . . [Full Text of this Article]

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Related Letters:

Renovascular Hypertension, Endothelial Function, and Oxidative Stress
Friedman A. N., Ritter C., Moreira J. C. F., Dal-Pizzol F., Ziegler M. G., Bao X., Matz R., Higashi Y., Chayama K., Yoshizumi M.
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N Engl J Med 2002; 347:1528-1530, Nov 7, 2002. Correspondence

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