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Previous Volume 346:2008-2010 June 20, 2002 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Oral et al. (Feb. 21 issue)¹ demonstrate convincingly that treatment with leptin decreases triglyceride levels, improves insulin resistance, and ameliorates diabetes in patients with lipodystrophy and leptin deficiency. Minokoshi et al. have recently demonstrated that leptin can activate the enzyme AMP-activated protein kinase in skeletal muscle, thereby increasing lipid combustion and glucose uptake and establishing a molecular basis for the lipid-lowering and insulin-sensitizing effect of leptin described in this study.²

In the light of their results, Oral et al. suggest that leptin is the chief fat-derived hormone required for glucose homeostasis. Used at physiologic levels, however, leptin . . . [Full Text of this Article]

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