FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 346:2079-2082 June 27, 2002 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Aviles, R. J. PubMed Citation

After the loss of integrity of cardiac myocyte membranes, intracellular macromolecules (cardiac biologic markers) diffuse into the cardiac interstitium, lymphatics, and microvasculature; eventually, they are detected in the peripheral circulation. The release kinetics of the various cardiac biologic markers depend in part on their location in the myocyte, their molecular weight, and the route by which they are cleared from the circulation. Cardiac-specific troponins are useful not only because they come close to fulfilling many of the criteria for an ideal biologic marker, but also because they convey prognostic information and can help frame therapeutic decisions regarding patients with acute . . . [Full Text of this Article]

This article has been cited by other articles:

• Warwick, G., Thomas, P. S., Yates, D. H. (2008). Biomarkers in pulmonary hypertension. Eur Respir J 32: 503-512 [Abstract] [Full Text]  
• Antman, E. M., Morrow, D. A. (2008). Biomarker Release After Percutaneous Coronary Intervention: A Message From the Heart. Circ Cardiovasc Intervent 1: 3-6 [Full Text]  
• Lauer, M. S. (2005). Cardiac Troponins and Renal Failure: The Evolution of a Clinical Test. Circulation 112: 3036-3037 [Full Text]  
• Henrikson, C. A., Chandra-Strobos, N. (2004). Troponin and outcomes. J Am Coll Cardiol 44: 1933-1934 [Full Text]  
• Ross, G. E., Bever, F. N., Uddin, Z., Devireddy, L., Gardin, J. M. (2004). Common Scenarios to Clarify the Interpretation of Cardiac Markers. JAOA: Journal of the American Osteopathic Association 104: 165-176 [Abstract] [Full Text]  
• Dunnick, J. K., Lieuallen, W., Moyer, C., Orzech, D., Nyska, A. (2004). Cardiac Damage in Rodents after Exposure to Bis(2-chloroethoxy)methane. Toxicol Pathol 32: 309-317 [Abstract]  
• Torbicki, A., Kurzyna, M., Kuca, P., Fijalkowska, A., Sikora, J., Florczyk, M., Pruszczyk, P., Burakowski, J., Wawrzynska, L. (2003). Detectable Serum Cardiac Troponin T as a Marker of Poor Prognosis Among Patients With Chronic Precapillary Pulmonary Hypertension. Circulation 108: 844-848 [Abstract] [Full Text]  
• Califf, R.M (2003). Cardiac markers in acute coronary syndromes--refining our knowledge. Eur Heart J 24: 136-137 [Full Text]  
• (2002). Predictive Value of Elevated Troponin T Levels Is Independent of Renal Function. JWatch Emergency Med. 2002: 4-4 [Full Text]