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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.
A 35-year-old woman presents with a three-month history of daily generalized hives. The hives are pruritic, red wheals that range from 1.5 to 8.0 cm (0.5 to 3 in.) in diameter. She has frequent episodes of lip swelling and has also had three episodes of tongue swelling, one of which was associated with tightness of the throat. How should she be evaluated
The Clinical Problem
Strategies and Evidence
Diagnosis
Evaluation
Therapy
Histamine H1Receptor Antagonists
Combined H1- and H2-Receptor Antagonists
Leukotriene Antagonists
Sympathomimetic Agents
Corticosteroids
Experimental Therapies
Areas of Uncertainty
Guidelines
Summary and Recommendations
Source Information
From the Department of Medicine, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, and KonishiMedical University of South Carolina Institute for Inflammation Research, Medical University of South Carolina, Charleston.
Address reprint requests to Dr. Kaplan at Medical University of South Carolina, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, 96 Johnathan Lucas St., Suite 812 CSD, P.O. Box 250623, Charleston, SC 29425, or at kaplana@musc.edu.
References
Related Letters:
Chronic Urticaria and Angioedema
Chowdhury B. A., Simonart T., Pfeiffer C., Kaplan A. P.
Extract |
Full Text |
PDF
N Engl J Med 2002;
347:220-222, Jul 18, 2002.
Correspondence
This article has been cited by other articles:
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