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Previous Volume 346:180-188 January 17, 2002 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Celiac sprue, also known as celiac disease and gluten-sensitive enteropathy, is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. There is clinical and histologic improvement on a strict gluten-free diet, and relapse when dietary gluten is reintroduced.¹ Accounts of celiac sprue date back to the first century A.D.² It was not until the 1940s, however, that the link to gluten ingestion was established; Dicke, a Dutch pediatrician, observed that the condition of children with celiac sprue improved during the food shortages of . . . [Full Text of this Article]

Epidemiology and Pathogenesis

Clinical Manifestations

Celiac Sprue in Children

Celiac Sprue in Adults

Associated Conditions

Diagnosis

Serologic Tests

Hematologic and Biochemical Tests

Tests of Intestinal Absorption

Biopsy of the Small Intestine

Imaging

Approach to Diagnostic Evaluation

Repeated Biopsy and Gluten Challenge

Treatment

Refractory Sprue and Enteropathy-Associated T-Cell Lymphoma

Source Information

From the Gastroenterology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston. Address reprints to Dr. Farrell at the Gastroenterology Division, Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Ave., Boston, MA 02215, or at rfarrell@caregroup.harvard.edu.

References

Related Letters:

Celiac Sprue
Colli A., Colucci A., Conte D., Gomollón F., Tribole E., Kupper C., Pietzak M., Spanier B. W.M., Dietz B., Mulder C. J.J., Farrell R. J., Kelly C. P.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:446-448, Aug 8, 2002. Correspondence

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