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Previous Volume 346:380-381 January 31, 2002 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We make the following observations about the review of cephalosporin allergy by Kelkar and Li (Sept. 13 issue).¹ First, anti-cephalosporin IgE antibody assays are available and are used by clinicians in Australasia. Second, specific haptenic determinants involved in hypersensitivity to cephalosporins have been identified.^2,3 Some of the cross-reactivity between cephalosporins and penicillin G results from the presence of IgE directed against a group as small as the methylene substituent linking the side chain to the rest of the penicillin molecule.² Cephalosporins exhibit greater heterogeneity of allergenic determinants than penicillin because of their extra side chain (R2) on . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Pichichero, M. E. (2005). A Review of Evidence Supporting the American Academy of Pediatrics Recommendation for Prescribing Cephalosporin Antibiotics for Penicillin-Allergic Patients. Pediatrics 115: 1048-1057 [Abstract] [Full Text]