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Correspondence
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Volume 346:381-382 January 31, 2002 Number 5
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Case 29-2001: Oncogenic Hypophosphatemic Osteomalacia

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To the Editor: Several important issues were overlooked in the Case Record of the 14-year-old boy with oncogenic hypophosphatemic osteomalacia (Sept. 20 issue).1 Terek was correct in stating that oncogenic hypophosphatemic osteomalacia has many similarities to X-linked hypophosphatemia. However, the onset of hypophosphatemia is not delayed in X-linked hypophosphatemia. Terek did not consider a diagnosis of autosomal dominant hypophosphatemic rickets, which has incomplete penetrance and a variable age of onset.2 Therefore, an affected child's parent may carry a mutation for autosomal dominant hypophosphatemic rickets that is nonpenetrant, and the child may have delayed phosphate wasting. It is important to note . . . [Full Text of this Article]

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