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Volume 346:452-453 February 7, 2002 Number 6
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Deep-Brain Stimulation in Parkinson's Disease

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To the Editor: The Deep-Brain Stimulation for Parkinson's Disease Study Group (Sept. 27 issue)1 reported the results of a prospective, double-blind, crossover study in patients with advanced Parkinson's disease, in whom electrodes were implanted in the subthalamic nucleus or pars interna of the globus pallidus and who then underwent bilateral high-frequency deep-brain stimulation. In the Discussion section, the authors wrote: "Although initiation of stimulation was associated with transient symptoms in some patients, we do not believe that this influenced the blinded assessment, since neither the patients nor the investigators were certain of whether stimulation was being given at the time." . . . [Full Text of this Article]

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