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Correspondence
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Volume 346:455 February 7, 2002 Number 6
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Selective Postoperative Inhibition of Gastrointestinal Opioid Receptors

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To the Editor: In their article on prophylaxis against postoperative ileus with the use of ADL 8-2698, Taguchi et al. (Sept. 27 issue)1 refer to our report on intravenous methylnaltrexone, a peripheral opioid antagonist.2 We call attention to an error in their description of our study population. Our study did not involve patients with pain from cancer but, rather, subjects receiving methadone-maintenance therapy, who are exquisitely sensitive to the withdrawal of opioids. The outcome measures thus included the laxation response, oral–cecal transit times, and symptoms of central opioid withdrawal.

All subjects in our treatment group had immediate laxation, and none . . . [Full Text of this Article]

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