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Correspondence
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Volume 346:457 February 7, 2002 Number 6
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Tranexamic Acid in Hereditary Hemorrhagic Telangiectasia

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To the Editor: Sabbà et al. (Sept. 20 issue)1 report the efficacy of tranexamic acid in reducing epistaxis in hereditary hemorrhagic telangiectasia. However, the title of their communication may be misleading. The authors do not mention the weight of the three patients they describe, an omission that hinders the evaluation of the doses administered. The total doses of tranexamic acid given to the three patients (4.0, 4.0, and 4.5 g per day), in contrast to the "unusually high" doses suggested by the title, correspond to the usual dose recommended for an average adult weighing 70 kg: 15 to 25 mg . . . [Full Text of this Article]

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