FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 346:614-616 February 21, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel disease, affect up to 1 million people in the United States. These related but distinct diseases are complex disorders with immunologic, environmental, and genetic components, each of which is the subject of intense investigation. In 1996 a gene conferring susceptibility to Crohn's disease was identified on chromosome 16 in families with multiple affected members. Now two groups, working independently and using different strategies, have identified the relevant gene at that locus.^1,2

The gene is named NOD2, and is similar to the R factor genes of plants that confer resistance to . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Mawdsley, J E, Rampton, D S (2005). Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut 54: 1481-1491 [Full Text]  
• Canny, G., Colgan, S. P. (2005). Events at the Host-Microbial Interface of the Gastrointestinal Tract I. Adaptation to a microbial world: role of epithelial bactericidal/permeability-increasing protein. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G593-G597 [Abstract] [Full Text]  
• Franchimont, D, Vermeire, S, El Housni, H, Pierik, M, Van Steen, K, Gustot, T, Quertinmont, E, Abramowicz, M, Van Gossum, A, Deviere, J, Rutgeerts, P (2004). Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 53: 987-992 [Abstract] [Full Text]  
• Chen, C.-M., Gong, Y., Zhang, M., Chen, J.-J. (2004). Reciprocal Cross-talk between Nod2 and TAK1 Signaling Pathways. J. Biol. Chem. 279: 25876-25882 [Abstract] [Full Text]  
• Freeman, S L, MacNaughton, W K (2004). Nitric oxide inhibitable isoforms of adenylate cyclase mediate epithelial secretory dysfunction following exposure to ionising radiation. Gut 53: 214-221 [Abstract] [Full Text]  
• Simopoulos, A. P. (2002). Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases. J. Am. Coll. Nutr. 21: 495-505 [Abstract] [Full Text]  
• Gutierrez, O., Pipaon, C., Inohara, N., Fontalba, A., Ogura, Y., Prosper, F., Nunez, G., Fernandez-Luna, J. L. (2002). Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-kappa B Activation. J. Biol. Chem. 277: 41701-41705 [Abstract] [Full Text]