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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.
A 35-year-old man who had undergone allogeneic hematopoietic-cell transplantation two years earlier for acute myeloid leukemia recently moved to a new town. He comes in for a general checkup because he tires easily and has frequent bouts of sinusitis. Physical examination reveals small central cataracts, some patches of vitiligo, and a dry mouth. Blood counts and the results of chemical analyses are
The Clinical Problem
Strategies and Evidence
Graft-versus-Host Disease
Immunologic Dysfunction
Endocrine Dysfunction
Secondary Cancers
Late Effects of Conditioning Regimens or Prophylaxis against GVHD
Areas of Uncertainty
Guidelines
Conclusions and Recommendations
Source Information
From the Adult Oncology Stem Cell Transplantation Program, Department of Adult Oncology, DanaFarber Cancer Institute, and the Department of Medicine, Brigham and Women's Hospital both in Boston.
Address reprint requests to Dr. Antin at the Department of Medicine, Brigham and Women's Hospital, 44 Binney St., Boston, MA 02115.
Related Letters:
Long-Term Care after Hematopoietic-Cell Transplantation in Adults
Boeckh M., Nichols W. G., Marr K. A., Antin J. H.
Extract |
Full Text |
PDF
N Engl J Med 2002;
347:1625-1626, Nov 14, 2002.
Correspondence
This article has been cited by other articles:
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