To the Editor: Davidson et al. (March 7 issue)1 describe fourpatients with pneumococcal pneumonia in whom therapy with orallevofloxacin failed. We report on a patient with pneumococcalpneumonia and bacteremia in whom meningitis and sepsis developedafter an initial clinical response to levofloxacin therapy.
A 79-year-old man was admitted to Saint Elizabeth's MedicalCenter in Boston in January 1999 with fever, dyspnea, and left-lower-lobepneumonia. Treatment with intravenous levofloxacin was started,and the fever resolved. Blood cultures grew Streptococcus pneumoniae,which was sensitive to ceftriaxone, with intermediate resistanceto penicillin. Treatment was switched to oral levofloxacin onthe . . . [Full Text of this Article]
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