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Volume 347:65-67 July 4, 2002 Number 1
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Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia

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 by Davidson, R.
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To the Editor: Davidson et al. (March 7 issue)1 describe four patients with pneumococcal pneumonia in whom therapy with oral levofloxacin failed. We report on a patient with pneumococcal pneumonia and bacteremia in whom meningitis and sepsis developed after an initial clinical response to levofloxacin therapy.

A 79-year-old man was admitted to Saint Elizabeth's Medical Center in Boston in January 1999 with fever, dyspnea, and left-lower-lobe pneumonia. Treatment with intravenous levofloxacin was started, and the fever resolved. Blood cultures grew Streptococcus pneumoniae, which was sensitive to ceftriaxone, with intermediate resistance to penicillin. Treatment was switched to oral levofloxacin on the . . . [Full Text of this Article]


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