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In a 1987 editorial accompanying two reports on the use of interleukin-2 for treating advanced cancer, John Durant, after several calls for caution, concluded that perhaps we were at the end of the beginning of the search for successful immunotherapy for cancer (N Engl J Med 1987;316:939-941). Fifteen years later, the third edition of Principles and Practice of the Biologic Therapy of Cancer illustrates the extraordinary development that has taken place in the field but also, as underlined by the variety of therapeutic approaches still being investigated, demonstrates that biologic therapy is still in its infancy and that there is
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