The detection of an increasing number of circulating recombinantstrains of human immunodeficiency virus type 1 (HIV-1) indicatesthat genetic recombination can occur in cells infected withtwo strains of HIV-1.1,2 Coinfection with two circulating strainsof HIV-1 has been detected in a few subjects in communitieswhere HIV-1 infection is endemic.3 Coinfection may result fromexposure to a second virus either shortly after the initialinfection or during the course of established HIV-1 infection;the latter circumstance is called superinfection.
Most viral infections induce lifelong immunity, but reinfectionwith respiratory viruses such as respiratory syncytial virusis common, most . . . [Full Text of this Article]
Case Report
Methods
Assays
Subtype-Specific Polymerase Chain Reaction
HIV-1 Proviral DNA PCR
Isolation and Growth of Subtypes AE and B in Vitro
Interferon- CD8 Enzyme-Linked Immunospot Assay
Results
Discussion
Source Information
From the Division of Infectious Diseases, University of Geneva, Geneva (S.J., M.-C.B., L.K., S.Y., B.H., L.P.); the Laboratoire d'Immunologie Cellulaire, Hôpital Pitié Salpêtrière, Paris (A.S., B.A.); and Clinical Development Medical Affairs, GlaxoSmithKline, Greenford, United Kingdom (L.-E.G.).
Address reprint requests to Dr. Perrin at the Laboratory of Virology, Geneva University Hospital, 1211 Geneva 14, Switzerland, or at luc.perrin@hcuge.ch.
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