IgA nephropathy is a relatively newly recognized disease, firstdescribed by Berger and Hinglais in 1968.1 It is now generallyknown to be the most common form of primary glomerulonephritisthroughout the world.2,3,4
Primary IgA nephropathy is an immune-complexmediatedglomerulonephritis defined immunohistologically by the presenceof glomerular IgA deposits accompanied by a variety of histopathologiclesions.5,6 Although primary IgA nephropathy receives the mostattention, many other diseases are also associated with glomerularIgA deposits (Table 1). The most common of these is SchönleinHenochpurpura. This condition may indeed be indistinguishable fromprimary IgA nephropathy and may represent a . . . [Full Text of this Article]
Demographic Features
Incidence
Causes and Genetic Factors
Pathogenesis
Pathology
Clinical Features
Outcome
Treatment
Angiotensin-ConvertingEnzyme Inhibitors
Corticosteroids
n3 Polyunsaturated Fatty Acids
Other Treatments
Renal Transplantation
Differential Diagnosis
Summary
Source Information
From the Division of Nephrology, Department of Medicine (J.V.D.), and the Department of Laboratory Medicine and Pathology (J.P.G.), Mayo Clinic and Mayo Foundation, Rochester, Minn.
Address reprint requests to Dr. Donadio at the Mayo Clinic, 200 First St. SW, Stabile 7-22, Rochester, MN 55905, or at donadio.james@mayo.edu.
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IgA Nephropathy
Heine G., Sester U., Kohler H., Wardle E. N., Sedlacek M., Donadio J. V., Grande J. P.
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N Engl J Med 2003;
348:79-81, Jan 2, 2003.
Correspondence
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[Full Text]