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Previous Volume 347:762-763 September 5, 2002 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Often, it is forgotten that the postmenopausal reduction in estrogen levels increases the levels of low-density lipoprotein (LDL) cholesterol and Lp(a) lipoprotein. Sometimes this effect is more important than and precedes the reduction in high-density lipoprotein (HDL) cholesterol levels. Postmenopausal hormonal changes cause a decrease in LDL-receptor activity, with a decrease in the apolipoprotein B–LDL catabolic rate.¹

This potential effect of estrogens on LDL cholesterol levels is another explanation for the increased rates of heart disease among postmenopausal women. Probably the best explanation is represented by the ratio of LDL to HDL cholesterol or the ratio of . . . [Full Text of this Article]

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