Edited by Emilio A. Emini. 544 pp., illustrated. Princeton, N.J., Princeton University Press, 2002. $75. ISBN 0-691-00454-4.
This book addresses our knowledge about replication of the humanimmunodeficiency virus (HIV), with a particular emphasis ondrugs and compounds that inhibit it. The last three chapterscover nonpharmaceutical prevention strategies, immunity to HIVinfection, and the prospects for the development of a vaccine.Current treatment of HIV infection exemplifies the practicaloutcome of rational drug design. In the 19 years since virologistsat the Institut Pasteur first isolated HIV, the detailed understandingof its molecular biology has led to successful drug regimensinvolving combinations of drugs that inhibit reverse transcriptionearly in the infection cycle and inhibit protein . . . [Full Text of this Article]
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