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Volume 347:850-852 September 12, 2002 Number 11
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Pulmonary Dead Space and Survival

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by Nuckton, T. J.
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To the Editor: Nuckton and associates (April 25 issue)1 report an abnormally high dead-space fraction (the ratio of dead-space ventilation to tidal volume, or VD/VT) early in the clinical course of the acute respiratory distress syndrome. Their inference of a heretofore unrecognized functional abnormality is unwarranted, because VD/VT was assessed on the basis of carbon dioxide excretion with the usual Bohr–Enghoff equation. By definition, the patients had refractory hypoxemia, which reflects a severe imbalance between alveolar ventilation (VA) and perfusion (Q), leading to a reduction in the efficiency of intrapulmonary gas transfer for both oxygen and . . . [Full Text of this Article]


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