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Previous Volume 347:857-858 September 12, 2002 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their letter about a patient with severe hyperosmolar metabolic acidosis due to a large dose of intravenous lorazepam (April 18 issue),¹ Tayar et al. err in attributing the observed acidosis and osmolarity to polyethylene glycol and overlook the greater contribution of propylene glycol. Each milliliter of Ativan injection (2 mg of lorazepam per milliliter, Wyeth–Ayerst Laboratories) contains 0.8 ml of propylene glycol.² We calculate that the cumulative lorazepam dose of 1696 mg would include 704 g or 678 ml of propylene glycol (molecular weight, 76) in addition to the 153 ml of polyethylene glycol (mean molecular . . . [Full Text of this Article]

Related Letters:

Severe Hyperosmolar Metabolic Acidosis Due to a Large Dose of Intravenous Lorazepam
Tayar J., Jabbour G., Saggi S. J.
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N Engl J Med 2002; 346:1253-1254, Apr 18, 2002. Correspondence

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