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Correspondence
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Volume 347:951 September 19, 2002 Number 12
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Seizure Induced by Insufflation of Bupropion

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To the Editor: A 16-year-old boy with a history of depression was brought to the emergency department after he had a generalized, tonic–clonic seizure. His only medication was bupropion (Wellbutrin SR) at a dose of 150 mg twice daily. He reported using marijuana "occasionally" and drinking approximately two 40-oz servings of beer several times a month during the preceding year. He denied using any other illicit substances. The findings on medical evaluation were otherwise unremarkable, and he was discharged with a diagnosis of bupropion-induced seizure. The patient later reported that, approximately one hour before the seizure, he had crushed six . . . [Full Text of this Article]




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