FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 347:1022-1024 September 26, 2002 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Prié, D. PubMed Citation

Phosphate leads two lives — an ancient intracellular one and a more recent extracellular one. Inside cells, phosphate has a structural role in nucleic acids and phospholipids, forms high-energy ester bonds (e.g., in adenosine triphosphate and guanosine triphosphate), and participates in cellular signaling through covalent phosphorylation of proteins and lipids. Outside cells, in animals with bones, the role of phosphate is quite different. Most extracellular phosphate is found in bone mineral. Because the concentrations of ionic calcium and phosphate in extracellular fluid are at, or exceed, their solubility product constant, elaborate controls have been developed to keep calcium–phosphate from precipitating . . . [Full Text of this Article]

This article has been cited by other articles:

• Berman, E., Nicolaides, M., Maki, R. G., Fleisher, M., Chanel, S., Scheu, K., Wilson, B.-A., Heller, G., Sauter, N. P. (2006). Altered bone and mineral metabolism in patients receiving imatinib mesylate.. NEJM 354: 2006-2013 [Abstract] [Full Text]  
• Bevilacqua, M., Dominguez, L. J., Righini, V., Valdes, V., Toscano, R., Sangaletti, O., Vago, T., Baldi, G., Barrella, M., Bianchi-Porro, G. (2005). Increased Gastrin and Calcitonin Secretion after Oral Calcium or Peptones Administration in Patients with Hypercalciuria: A Clue to an Alteration in Calcium-Sensing Receptor Activity. J. Clin. Endocrinol. Metab. 90: 1489-1494 [Abstract] [Full Text]  
• Ebert, R., Jovanovic, M., Ulmer, M., Schneider, D., Meissner-Weigl, J., Adamski, J., Jakob, F. (2004). Down-Regulation by Nuclear Factor {kappa}B of Human 25-Hydroxyvitamin D3 1{alpha}-Hydroxylase Promoter. Mol. Endocrinol. 18: 2440-2450 [Abstract] [Full Text]  
• Rowe, P. S.N. (2004). THE WRICKKENED PATHWAYS OF FGF23, MEPE AND PHEX. Crit. Rev. Oral Biol. Med. 15: 264-281 [Abstract] [Full Text]  
• Baum, M., Loleh, S., Saini, N., Seikaly, M., Dwarakanath, V., Quigley, R. (2003). Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin. Proc. Natl. Acad. Sci. USA 100: 11098-11103 [Abstract] [Full Text]  
• Tenenhouse, H. S., Murer, H. (2003). Disorders of Renal Tubular Phosphate Transport. J. Am. Soc. Nephrol. 14: 240-247 [Full Text]