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Volume 347:1037-1040 September 26, 2002 Number 13
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Oophorectomy in Carriers of BRCA Mutations

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 by Haber, D.
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 by Kauff, N. D.
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 by Rebbeck, T. R.
-PubMed Citation
To the Editor: Kauff et al. (May 23 issue)1 present data suggesting that salpingo-oophorectomy provides protection against breast or gynecologic cancer in women with a BRCA1 or BRCA2 mutation. Although the follow-up period was relatively short and overall survival data are not yet available, the authors should be applauded for undertaking the only known prospective study of its kind. Since there are other options for reducing the risk of breast cancer,2,3 we believe that the benefit of salpingo-oophorectomy should be evaluated separately in women with breast cancer and in those with gynecologic cancer. In a separate analysis shown in Table . . . [Full Text of this Article]


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