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Previous Volume 347:1119-1121 October 3, 2002 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Massive organophosphorus-compound intoxication is relatively common. Although uncommon, delayed neurotoxicity may also occur in humans.¹ Persons with organophosphorus-compound poisoning have acute toxic effects, with a cholinergic crisis due to inhibition of acetylcholinesterase. Some persons subsequently have organophosphate-induced delayed neuropathy, which may be related to the inhibition of neurotoxic esterase.² Organophosphate-induced delayed neuropathy results in damage to both the peripheral and the central nervous systems.³ The exact sequence of lesions in these systems remains controversial, and few reports have discussed central nervous system neuropathological changes in humans. We describe a patient who had a classic acute cholinergic crisis . . . [Full Text of this Article]

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