Since the first culture of Helicobacter pylori 20 years ago,the diagnosis and treatment of upper gastroduodenal diseasehave changed dramatically. Peptic ulcer disease is now approachedas an infectious disease, in which elimination of the causativeagent cures the condition. The role of H. pylori infection ingastric cancers is increasingly recognized, and its role inother diseases of the upper gastrointestinal tract is beingevaluated. Enormous progress has been achieved in determiningthe pathogenesis of this infection. Effective antimicrobialtherapy is available, although there is still no ideal treatment,and indications for therapy continue to evolve. This review. . . [Full Text of this Article]
Epidemiology and Transmission
Pathogenesis
Host Response to H. pylori
Clinical Outcomes of Infection
Diagnostic Tests
Treatment of H. pylori Infection
First-Line Therapies
Proton-Pump-Inhibitor–Based Triple Therapies
Ranitidine Bismuth Citrate–Based Therapies
Bismuth-Based Triple Therapies
Second-Line Therapies
Indications for Therapy
Perspective
Source Information
From the Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany (S.S.); and the Division of Gastroenterology and Hepatology, Lausanne University Medical Center, Lausanne, Switzerland (P.M.).
Address reprint requests to Dr. Michetti at the Division of Gastroenterology and Hepatology, BH10N-531, Centre Hospitalier Universitaire Vaudois, CH-1010 Lausanne, Switzerland, or at pierre.michetti@chuv.hospvd.ch.
Related Letters:
Helicobacter pylori
Meyer J. M., Hopkins R. J., Mascitelli L., Pezzetta F.
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N Engl J Med 2003;
348:363-365, Jan 23, 2003.
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