FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 347:1203-1204 October 10, 2002 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Cytotoxic T lymphocytes control viral infections by lysing infected cells and secreting soluble factors (cytokines) that enhance antiviral immunity and suppress infection. The importance of antiviral killer cells in controlling acute infection with human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in macaque monkeys has clearly been demonstrated: resolution of the first wave of viremia coincides with the development of HIV-specific cytotoxic T lymphocytes, and macaques depleted of killer cells control SIV poorly. Some viruses, especially herpesviruses, hepatitis viruses, and immunodeficiency viruses, have devised clever strategies to outwit killer cells and thereby persist for the life of . . . [Full Text of this Article]

This article has been cited by other articles:

• Brainard, D. M., Tharp, W. G., Granado, E., Miller, N., Trocha, A. K., Ren, X.-H., Conrad, B., Terwilliger, E. F., Wyatt, R., Walker, B. D., Poznansky, M. C. (2004). Migration of Antigen-Specific T Cells Away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol. 78: 5184-5193 [Abstract] [Full Text]