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Previous Volume 347:1281-1282 October 17, 2002 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In contrast to previous trials,^1,2 the study reported by Abu-Laban et al. (May 16 issue)³ showed no beneficial effects of fibrinolysis in patients with cardiac arrest and pulseless electrical activity. However, Abu-Laban et al. studied a subgroup with an exceptionally poor prognosis.⁴ We are not aware of other studies in which there were no survivors in the placebo group. Even therapeutic strategies with proven efficacy in patients with cardiac arrest, such as hypothermia,⁵ would have failed in this study population. To test validly for efficacy, it is important to study populations that might also survive without specific . . . [Full Text of this Article]

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