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Volume 347:1282-1285 October 17, 2002 Number 16
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Salmeterol for the Prevention of High-Altitude Pulmonary Edema

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by Voelkel, N. F.
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by Sartori, C.
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To the Editor: Sartori and colleagues (May 23 issue)1 demonstrate the marked benefits of salmeterol in the secondary prevention of high-altitude pulmonary edema. The authors propose that this benefit occurs through changes in pulmonary transepithelial sodium transport rather than hemodynamic effects, because salmeterol did not alter the heart rate or peak pulmonary pressures.

However, the authors did not assess the nasal transepithelial potential difference at high altitude, nor did they determine the effect of salmeterol administration on this gradient. Furthermore, there was no measurement of mean pulmonary pressure, cardiac output, central filling pressures, or systemic blood pressure. In addition, only . . . [Full Text of this Article]



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