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Previous Volume 347:1359-1360 October 24, 2002 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Until a few years ago, we did not understand the pivotal role of platelets in orchestrating the process of inflammation. The discovery in 1998 that CD40 ligand is shed from activated platelets to directly initiate inflammation of the vessel wall¹ was a seminal event. It led to a new understanding of the function of platelets, clarifying that, in addition to their well-established function of governance of homeostasis, platelets also have the integrated role of principal modulator of inflammation. Not only do platelets account for 90 percent of the CD40 ligand in the body, but they contain and produce key inflammatory . . . [Full Text of this Article]

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Aspirin and Mortality from Coronary Bypass Surgery
Chesebro J. H., Fuster V., Pugo F. J., Karzai W., Priebe H.-J., Mangano D. T.
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N Engl J Med 2003; 348:1057-1059, Mar 13, 2003. Correspondence

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