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Correspondence
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Volume 347:1377-1379 October 24, 2002 Number 17
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Cardiac Syndrome X

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 by Panza, J. A.
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 by Panting, J. R.
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To the Editor: There may be an alternative explanation for the observations made by Panting et al. (June 20 issue)1 in their elegant study of patients with cardiac syndrome X. Although the heart-rate response to adenosine infusion is not given, the occurrence of "adenosine-induced tachycardia" is mentioned. Huang et al.2,3 showed that cardiac sensory-nerve endings in the canine heart possess specific adenosine receptors that can be activated by endogenous adenosine released from the heart. Exogenous adenosine administered to ventricular sensory-nerve endings greatly stimulates cardiac sensory neurons in the upper thoracic dorsal-root ganglia that project cardiac nociceptive input to the spinal . . . [Full Text of this Article]




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